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KMID : 1189420070200020068
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 2 p.68 ~ p.76
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The Effects of Sulfur extract on Anti-Inflammation and Anti-Propionibacterium acnes
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Lee Seon-Yong
Seo Hyeong-Sik
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Abstract
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Objectives: This experimental study was performed to investigate the effects of Sulfur extract on anti-inflammation and anti-Propionibacterium acnes.
Methods: The cytotoxicity of Sulfur extract about viability of Raw 264.7 cell were tested using a colorimetric tetrazolium assay(MTT assay). To investigate the anti-inflammation effects of Sulfur extract on LPS-induced macrophage Raw 264.7 cell, we used ELISA kit and Western blots. We evaluated anti-oxidation effects of Sulfur extract on HaCaT cell by Enzyme recycling method. And we investigated the inhibitory effects of Sulfur extract on Propionibactrium acnes using paper disk diffusion method.
Results: 1. Sulfur extract has a little cytotoxicity in Raw 264.7 cell. 2. Concentration of Sulfur extract inhibited the production of NO in the Raw 264.7 cell stimulated with LPS. 3. Sulfur extract showed a oxidation inhibition effect by decreasing the DPPH radicals. 4. Sulfur extract has not the significant inhibition effect of Propionibactrium acnes.
Conclusions: These results indicate that Sulfur extract has anti-inflammation and anti-oxidation effects. If further study is performed, the use of Sulfur extract will be valuable and benificial in the therapy of Propionibactrium acnes.
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KEYWORD
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Sulfur, Sulfurextract, Propionibactriumacnes, Anti-inflammation, Anti-oxidation, DPPH
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